Pathways
Biosynthesis of Progesterone
Description:
Cholesterol is the common precursor of all steroid hormones and is biosynthesized in many tissues. Steroid hormones are characterized by a common basic structure of cyclopentane-perhydro-phenantrene, a polycyclic complex of 17 carbon atoms forming a four-ring system. Altering a side chain or subsistent group of a cholesterol molecule produces various steroids molecules. Pregnenolone and progesterone are molecules derived from cholesterol (Ref.1&2).
Cholesterol is converted to pregnenolone inside the mitochondr...
References:
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Contact sites from human placental mitochondria: characterization and role in progesterone synthesis.
Arch Biochem Biophys. 2003 May 15;413(2):172-81. -
Physiology, production and action of progesterone.
Acta Obstet Gynecol Scand. 2015 Nov;94 Suppl 161:8-16. doi: 10.1111/aogs.12771. Review. -
. Molten globule structure and steroidogenic activity of N-218 MLN64 in human placental mitochondria.
Endocrinology. 2004 Apr;145(4):1700-7. Epub 2004 Jan 8. -
Progesterone synthesis in the nervous system: implications for myelination and myelin repair.
Front Neurosci. 2012 Feb 8;6:10. doi: 10.3389/fnins.2012.00010. eCollection 2012.
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